Sodium 4-aminosalicylate Cas 133-10-8

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Chemical Name: Sodium 4-aminosalicylate
CAS No.: 133-10-8
Molecular Fomula: C7H6NNaO3
Molecular weight: 175.12
Appearance: White to off-white crystalline powder
Assay: ≥98.0%

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Comprehensive Guide to Sodium 4-Aminosalicylate (CAS 133-10-8)

Table of Contents

1. Product Overview & Specifications

Parameter Specification
CAS Number 133-10-8
Molecular Formula C7H6NNaO3
Molecular Weight 175.12 g/mol
Appearance White to off-white crystalline powder
Purity ≥98% (HPLC)
Solubility Water: 50 mg/mL (20°C)
Storage 2-8°C in airtight container

2. Key Applications

Pharmaceutical Applications

Primary use as second-line anti-tuberculosis agent, particularly in multidrug-resistant TB (MDR-TB) cases. Mechanism: Inhibits folate synthesis in Mycobacterium tuberculosis.

Research Applications

  • Biochemical reagent for studying bacterial resistance mechanisms
  • Intermediate in synthesis of PAS derivatives

Industrial Applications

  • Preservative in specialty chemical formulations
  • Precursor for synthesis of sulfonamide antibiotics

3. Comparative Analysis

Parameter Sodium 4-Aminosalicylate 4-Aminosalicylic Acid Sodium Aminosalicylate (Generic)
CAS Number 133-10-8 65-49-6 Varies
Solubility in Water High (50 mg/mL) Low (5 mg/mL) 40-45 mg/mL
pH Stability 7.0-9.0 2.0-4.0 6.5-8.5
Pharmaceutical Use Preferred formulation Limited due to acidity Variable quality

4. Usage Guidelines

Storage Recommendations

  • Maintain tight container closure to prevent oxidation
  • Protect from light exposure

Handling Precautions

  • Use PPE: Nitrile gloves, safety goggles
  • pH adjustment required for IV formulations (target pH 6.8-7.4)

5. Industry Case Studies

Case Study 1: TB Treatment Optimization

Client: Indian Pharma Co. (Mumbai-based manufacturer)
Application: Developed sustained-release TB tablets combining sodium 4-aminosalicylate with rifampicin
Result: 23% improvement in patient compliance vs. standard PAS formulations

Case Study 2: Chemical Intermediate Production

Client: German Chemical Solutions GmbH
Application: Synthesis of anti-inflammatory PAS derivatives
Outcome: Achieved 98.7% purity in final API batches

6. Technical Inquiry & Support

For product specifications, COA, or bulk pricing:

Frequently Asked Questions

Q: Difference between sodium and potassium salts?
A: Sodium salt offers better solubility (50 vs 35 mg/mL) and lower hygroscopicity.

Q: Available package sizes?
A: R&D samples: 100g-1kg, Bulk orders: 25kg drum quantities.

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