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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine CAS 444731-75-3

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Chemical Name: N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
CAS No.: 444731-75-3
Molecular Fomula: C14H14ClN5
Molecular weight: 287.75
Appearance: Light yellow powder
Assay: 99 % min

Estimated Delivery: Sat, Aug 30 – Wed, Sep 03

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N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine (CAS 444731-75-3): Comprehensive User Guide

1. Product Overview & Specifications
2. Key Applications & Use Cases
3. Industry Case Studies
4. Technical Comparison
5. Contact for Inquiries

1. Product Overview & Specifications

CAS Number: 444731-75-3

Molecular Formula: C₁₅H₁₅ClN₆

Molecular Weight: 314.78 g/mol

Appearance: White to off-white crystalline powder

Purity: ≥98% (HPLC)

Storage: 2-8°C in airtight containers

Parameter Comparison

Parameter	CAS 444731-75-3	Similar Compound A	Similar Compound B
Solubility (DMSO)	50 mg/mL	30 mg/mL	45 mg/mL
Stability	24 months	18 months	12 months

2. Key Applications & Use Cases

Pharmaceutical Intermediates

Used in synthesis of kinase inhibitors for oncology research, particularly targeting EGFR and VEGFR pathways.

Organic Synthesis

Critical intermediate for constructing pyrimidine-indazole hybrid molecules in catalytic reactions.

3. Industry Case Studies

Case Study 1: ABC Pharma (USA)

Application: Development of third-generation EGFR inhibitors

Result: Achieved 85% inhibition rate at 10 μM concentration in vitro

Case Study 2: XYZ Biotech (Germany)

Application: High-throughput screening of kinase inhibitor libraries

Result: Identified 3 lead compounds with IC₅₀ < 100 nM

4. Technical Comparison

Feature	CAS 444731-75-3	Competitor Products
Synthetic Yield	72-78%	60-65%
Byproduct Formation	<3%	5-8%

5. Contact for Inquiries

Request custom synthesis or bulk pricing:

Email: info@vivalr.com

Phone: (86) 15866781826

✉️ Lead Time: 2-4 weeks for 100g to 1kg quantities

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