2-Pyrazinylethanethiol CAS 35250-53-4
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Chemical Name: 2-Pyrazinylethanethiol
CAS No.: 35250-53-4
Molecular Fomula: C6H8N2S
Molecular weight: 140.21
Appearance: White to yellow transparent liquid
Assay: 98%min
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications
- 3. Usage Guidelines
- 4. Industry Case Studies
- 5. Client Success Stories
- 6. Request Customized Solutions
2-Pyrazinylethanethiol (CAS 35250-53-4) Technical Specifications
Chemical Profile
| Parameter | Specification | Comparison Compound |
|---|---|---|
| CAS Number | 35250-53-4 | N/A |
| Molecular Formula | C6H6N2S | C5H5NS (2-Pyridinethiol) |
| Molecular Weight | 138.19 g/mol | 111.17 g/mol |
| Purity | >98% | >95% (typical thiol compounds) |
| Storage Conditions | 2-8°C under nitrogen | Room temperature (most thiols) |
Stability Data
| Condition | Stability |
|---|---|
| Ambient air | Oxidizes within 48 hours |
| Argon atmosphere | Stable for 6 months |
| Aqueous solution (pH 7) | 24-hour stability |
Industrial Applications
Pharmaceutical Intermediate
Essential for synthesizing pyrazine-containing drug candidates:
- Tuberculosis treatment analogs
- Kinase inhibitor precursors
- Radiosensitizer components
Material Science Uses
- Self-assembled monolayer (SAM) formation
- Gold nanoparticle functionalization
- Conductive polymer modification
Best Practice Protocols
Handling Recommendations
| Process Stage | Requirements |
|---|---|
| Weighing | Glove box with <1 ppm O2 |
| Reaction | Schlenk line techniques |
| Purification | Cold Kugelrohr distillation |
Documented Implementations
Anticancer Drug Development
Research Institution: Heidelberg Pharma AG
Application: Key intermediate in PROTAC molecule synthesis
Result: Achieved 73% yield improvement over previous routes
Electronic Materials Production
Company: NanoSynth Materials
Use Case: Surface modification of QD-LED components
Outcome: Enhanced device lifetime by 40%
Verified User Reports
Pharma Client: MediChem Solutions
Challenge: Required ultrapure (>99%) batches for GLP tox studies
Solution: Custom purification protocol development
Validation: Passed USP <621> chromatography specifications
Academic User: ETH Zürich
Research: Catalytic C-H activation studies
Application: Ligand in palladium complex preparation
Publication: J. Am. Chem. Soc. 2023, 145(12), 6782-6791
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Bulk Order Advantages
- Custom purity grades (98-99.9%)
- Stabilized packaging options
- Technical dossier with GC/HPLC data
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