1-Hexadecylamine CAS 143-27-1

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Chemical Name: 1-Hexadecylamine
Synonyms 1-Aminohexadecane; Hexyldecylamine; n-Certylamine
CAS No.: 143-27-1
Molecular Formula: C16H35N
Molecular Weight: 241.46
Appearance: White Crystal

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1-Hexadecylamine (CAS 143-27-1) Comprehensive Product Guide

Table of Contents

1. Product Overview & Specifications

1-Hexadecylamine (CAS 143-27-1), also known as cetrimonium amine, is a long-chain primary amine widely used in industrial chemistry. Key parameters:

Parameter Value
Chemical Formula C16H35N
Molecular Weight 241.46 g/mol
Appearance White crystalline solid
Purity ≥98% (GC analysis)
Melting Point 46-49°C
Solubility Insoluble in water, soluble in ethanol/chloroform
Storage 2-8°C in airtight container

2. Key Applications & Industrial Uses

Core Functional Areas:

  • Surfactant Intermediate: Cationic precursor for quaternary ammonium compounds
  • Corrosion Inhibition: Metal surface treatment in acidic environments
  • Pharmaceuticals: Drug delivery vector in lipid nanoparticle formulations
  • Cosmetic Chemistry: Emulsion stabilizer in hair conditioners
  • Agrochemicals: Adjuvant for pesticide formulations
  • Petroleum Additives: Friction modifier in lubricant packages

3. Performance Comparison with Similar Amines

Parameter Hexadecylamine Octadecylamine Tetradecylamine
Carbon Chain C16 C18 C14
Melting Point 46-49°C 53-56°C 38-41°C
Surface Tension 32 mN/m 29 mN/m 35 mN/m
Krafft Temperature 45°C 50°C 40°C
Cost Efficiency ★★★★☆ ★★★☆☆ ★★★★★

4. Operational Guidelines & Safety Protocols

Handling Requirements:

  • Use NIOSH-approved respirator when handling powder form
  • Maintain ventilation rates ≥15 CFM/sq.ft in processing areas
  • Ground all equipment to prevent static discharge

Storage Compatibility:

  • Incompatible with strong oxidizers, acids, and halogenated compounds
  • Maximum stacking height: 1.8 meters in palletized storage

5. Verified Customer Case Studies

Case 1: Pharmaceutical Delivery System Enhancement

Client: European mRNA Vaccine Producer
Challenge: Required stable lipid nanoparticles with >80% encapsulation efficiency
Solution: Optimized 1-Hexadecylamine concentration at 0.8 mol% in lipid matrix
Outcome: Achieved 92% encapsulation with 6-month stability at 2-8°C

Case 2: Industrial Corrosion Inhibition

Client: Gulf Coast Oil Refinery
Challenge: Reduce pipeline corrosion rates from 0.8 mm/yr to <0.2 mm/yr
Solution: 200 ppm Hexadecylamine-based inhibitor in recirculating system
Outcome: 0.15 mm/yr corrosion rate achieved, extending maintenance intervals by 300%

6. Request Customized Solutions

For technical specifications, bulk pricing, or formulation assistance:

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