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1-Hexadecylamine CAS 143-27-1

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Chemical Name: 1-Hexadecylamine
Synonyms 1-Aminohexadecane; Hexyldecylamine; n-Certylamine
CAS No.: 143-27-1
Molecular Formula: C16H35N
Molecular Weight: 241.46
Appearance: White Crystal

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1-Hexadecylamine (CAS 143-27-1) Comprehensive Product Guide

1. Product Overview & Specifications
2. Key Applications & Industrial Uses
3. Performance Comparison with Similar Amines
4. Operational Guidelines & Safety Protocols
5. Verified Customer Case Studies
6. Request Customized Solutions

1. Product Overview & Specifications

1-Hexadecylamine (CAS 143-27-1), also known as cetrimonium amine, is a long-chain primary amine widely used in industrial chemistry. Key parameters:

Parameter	Value
Chemical Formula	C₁₆H₃₅N
Molecular Weight	241.46 g/mol
Appearance	White crystalline solid
Purity	≥98% (GC analysis)
Melting Point	46-49°C
Solubility	Insoluble in water, soluble in ethanol/chloroform
Storage	2-8°C in airtight container

2. Key Applications & Industrial Uses

Core Functional Areas:

Surfactant Intermediate: Cationic precursor for quaternary ammonium compounds
Corrosion Inhibition: Metal surface treatment in acidic environments
Pharmaceuticals: Drug delivery vector in lipid nanoparticle formulations
Cosmetic Chemistry: Emulsion stabilizer in hair conditioners
Agrochemicals: Adjuvant for pesticide formulations
Petroleum Additives: Friction modifier in lubricant packages

3. Performance Comparison with Similar Amines

Parameter	Hexadecylamine	Octadecylamine	Tetradecylamine
Carbon Chain	C16	C18	C14
Melting Point	46-49°C	53-56°C	38-41°C
Surface Tension	32 mN/m	29 mN/m	35 mN/m
Krafft Temperature	45°C	50°C	40°C
Cost Efficiency	★★★★☆	★★★☆☆	★★★★★

4. Operational Guidelines & Safety Protocols

Handling Requirements:

Use NIOSH-approved respirator when handling powder form
Maintain ventilation rates ≥15 CFM/sq.ft in processing areas
Ground all equipment to prevent static discharge

Storage Compatibility:

Incompatible with strong oxidizers, acids, and halogenated compounds
Maximum stacking height: 1.8 meters in palletized storage

5. Verified Customer Case Studies

Case 1: Pharmaceutical Delivery System Enhancement

Client: European mRNA Vaccine Producer
Challenge: Required stable lipid nanoparticles with >80% encapsulation efficiency
Solution: Optimized 1-Hexadecylamine concentration at 0.8 mol% in lipid matrix
Outcome: Achieved 92% encapsulation with 6-month stability at 2-8°C

Case 2: Industrial Corrosion Inhibition

Client: Gulf Coast Oil Refinery
Challenge: Reduce pipeline corrosion rates from 0.8 mm/yr to <0.2 mm/yr
Solution: 200 ppm Hexadecylamine-based inhibitor in recirculating system
Outcome: 0.15 mm/yr corrosion rate achieved, extending maintenance intervals by 300%

6. Request Customized Solutions

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