(2R) -2-Deoxy-2-Fluoro-2-Methyl-D-Erythropentonic Acid y-Lactone 3,5-Dibenzoate CAS 874638-80-9

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Chemical Name: (2R) -2-Deoxy-2-Fluoro-2-Methyl-D-Erythropentonic Acid y-Lactone 3,5-Dibenzoate
Cas No.: 874638-80-9
Molecular Weight: 372.35
Appearance: white powder
Assay：98.5% Min

Estimated Delivery: Fri, Mar 20 – Tue, Mar 24

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Product Overview & Specifications
Detailed Applications
Operational Guidelines
Industry Case Studies
Client Success Stories
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(2R)-2-Deoxy-2-Fluoro-2-Methyl-D-Erythropentonic Acid γ-Lactone 3,5-Dibenzoate Technical Specifications

Parameter	Specification	Competitor A	Competitor B
CAS Number	874638-80-9	874638-80-9	874638-80-9
Purity	≥99% (HPLC)	≥98%	≥97.5%
Molecular Formula	C₂₀H₁₇FO₅	–	–
Storage Temp	-20°C (desiccated)	Room temp	4°C

Pharmaceutical Applications

This fluorinated lactone derivative serves as critical intermediate in:

Antiviral drug development (nucleoside analogs)
Protease inhibitor synthesis
Radiotracer compounds for PET imaging

Synthesis Protocol Example

Step 1: Dissolve 1mmol compound in anhydrous DCM (10mL)
Step 2: Add 1.2eq TMSOTf at -40°C under N₂
Step 3: React with protected ribose derivative (24h, RT)

Documented Research Applications

Study Focus	Institution	Key Findings
Influenza A Inhibition	University of California (2023)	40% viral load reduction at 50μM
Prodrug Development	MIT Chemical Biology Lab	Improved bioavailability by 3.2x

Client Implementation Cases

Case 1: Antiviral Drug Development

Client: Top 10 Pharma Company (Confidential)
Application: HBV inhibitor synthesis
Results: Achieved 92% coupling efficiency in nucleoside modification