Pyridine-3-sulfonyl chloride CAS 16133-25-8

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Chemical Name: pyridine-3-sulfonyl chloride
Synonyms: m-Pyridinesulfonyl chloride
CAS No.: 16133-25-8
Molecular Fomula: C5H4ClNO2S
Molecular weight: 177.61
Appearance: Colorless to pale yellow liquid
Assay: 99 % min

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Pyridine-3-sulfonyl Chloride (CAS 16133-25-8): Comprehensive User Guide

1. Product Overview & Specifications
2. Key Applications
3. Usage Guidelines
4. Case Studies
5. Customer Success Stories
6. Contact for Custom Solutions

1. Product Overview & Specifications

Pyridine-3-sulfonyl chloride (CAS 16133-25-8) is a specialized sulfonating agent with the molecular formula C₅H₄ClNO₂S. It is widely used in pharmaceutical and chemical synthesis.

Parameter	Specification	Competitor A	Competitor B
Purity	≥98%	≥95%	≥97%
Melting Point	89-92°C	85-88°C	90-93°C
Storage	2-8°C, inert atmosphere	Ambient	4-10°C

2. Key Applications

Pharmaceutical Intermediates: Synthesis of sulfonamide-based drugs.
Agrochemicals: Production of herbicidal compounds.
Material Science: Modification of polymer surfaces.

3. Usage Guidelines

Typical Reaction Conditions

Solvent: Dichloromethane or THF
Temperature: 0-5°C (initial), room temperature for completion
Molar Ratio: 1:1.2 (substrate:sulfonyl chloride)

4. Case Studies

Case 1: Anticancer Drug Synthesis

Used in a 3-step synthesis of PD-1/PD-L1 inhibitors, achieving 82% yield with >99% purity.

Case 2: Polymer Functionalization

Enhanced hydrophilicity of polyetheretherketone (PEEK) membranes for biomedical applications.

5. Customer Success Stories

Customer	Application	Result
PharmaTech Inc. (USA)	HIV protease inhibitor development	Reduced synthesis steps from 5 to 3
EuroChem Research (Germany)	Herbicide formulation	15% efficacy improvement

6. Contact for Custom Solutions

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