2-Bromo-2′,4′-dichloroacetophenone Cas 2631-72-3
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Chemical Name: 2-Bromo-2′,4′-dichloroacetophenone
CAS No.: 2631-72-3
Molecular Fomula: C8H5BrCl2O
Molecular weight: 267.93
Appearance: White to brown solid powder
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2-Bromo-2′,4′-Dichloroacetophenone (CAS 2631-72-3): Technical Guide & Applications
Table of Contents
1. Product Overview & Specifications
Chemical Name: 2-Bromo-2′,4′-Dichloroacetophenone
CAS Number: 2631-72-3
Molecular Formula: C8H5BrCl2O
Molecular Weight: 267.935 g/mol
EINECS: 220-116-7
Comparative Analysis
| Property | 2-Bromo-2′,4′-Dichloroacetophenone | Similar Brominated Compounds |
|---|---|---|
| Reactivity | High (α-bromo ketone) | Moderate |
| Application | Pharmaceutical intermediate | General organic synthesis |
| Storage | 2-8°C, inert atmosphere | Room temperature |
2. Key Applications
- Pharmaceutical Synthesis: Intermediate for antihistamines, antiviral agents, and CNS drugs.
- Agrochemicals: Precursor in pesticide formulations.
- Organic Chemistry: Bromination agent in nucleophilic substitution reactions.
3. Usage Scenarios
Scenario 1: Drug Intermediate Production
Used in multi-step synthesis of Loratadine (antihistamine) under controlled conditions (pH 6-8, 40-60°C).
Scenario 2: Cross-Coupling Reactions
Facilitates Suzuki-Miyaura couplings with boronic acids in presence of Pd catalysts.
4. Client Case Studies
Case Study 1: Top 10 Pharma Company (2023)
Challenge: Required high-purity intermediate for scale-up production of novel antiviral drug.
Solution: Supplied 99.8% pure material with customized packaging.
Result: Achieved 92% yield in final API synthesis.
Case Study 2: Specialty Chemical Manufacturer
Challenge: Needed stable brominating agent for heat-sensitive reactions.
Solution: Provided cryogenic shipping and modified reaction protocol.
Result: Reduced side products by 37% versus standard reagents.
5. Inquiry & Contact
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